| 1 |
CCTOP
|
https://cctop.ttk.hu
|
2014 |
2864462
|
3671748
|
|
|
CCTOP predicts the topology i.e. localization of membrane spanning regions and
orientation of segments between them for transmembrane proteins. The prediction is a consensus
of 10 different methods enchanced with available structural and experimental information of any
homologous proteins in the TOPDB database.
|
| 2 |
TSTMP
|
http://tstmp.enzim.ttk.mta.hu
|
2016 |
390619
|
32281
|
|
|
TSTMP is a database designed to help the target selection of human transmembrane
proteins for structural genomics projects.
|
| 3 |
HTP
|
This server was shut down in 2023.
|
2016 |
315017
|
n.a.
|
|
|
The Human Transmembrane Proteome database and web service are a comprehensive
resources of the α-helical human transmembrane proteins. It contains topology and structure
information about the human α-helical transmembrane proteins classified into reliability levels.
|
| 4 |
PolarProtDb
|
https://polarprotdb.ttk.hu
|
2020 |
255770
|
1889
|
|
|
PolarProtDb is the most comprehensive database containing experimentally verified
mammalian proteins that display polarized sorting or secretion, focusing at epithelial polarity.
In addition to the source cells or tissues, homology-based inferences and transmembrane topology
(if applicable) are all provided together.
|
| 5 |
MemDis
|
https://memdis.ttk.hu
|
2020 |
4773
|
21025
|
|
|
MEMDIS is a novel prediction method, utilizing convolutional neural network and long short-term memory networks for predicting disordered regions in TMPs. MEMDIS achieved the highest prediction accuracy on TMP specific dataset among other popular IDR prediction methods.
|
| 6 |
PolarProtPred
|
https://polarprotpred.ttk.hu
|
2021 |
11555
|
65624
|
|
|
PolarProtPred may offer help to experimentalists to identify or better characterize
molecular networks regulating the distribution of transporters or surface receptors (including viral
entry receptors like COVID-19) by predicting polar distribution of transmembrane proteins.
|
| 7 |
TmAlphaFold
|
https://tmalphafold.ttk.hu
|
2022 |
41842
|
391976
|
|
|
TmAlphaFold database provides open access to the membrane orientation of all
alpha-helical transmembrane protein's structure predicted by AlphaFold together with the
evaluation of the predicted structures.
|
| 8 |
LeishMANIAdb
|
https://leishmaniadb.ttk.hu
|
2023 |
11911
|
625142
|
|
|
The leishMANIAdb contains experimental, computational and annotated information
about proteins from Leishmania species.
|
| 9 |
UniTmp/PDBTM
|
https://pdbtm.unitmp.org
|
2023 |
278198
|
1088147
|
|
|
PDBTM is the first comprehensive and up-to-date transmembrane protein selection of the Protein Data Bank (PDB). The database was created by scanning all PDB entries with TMDET algorithm.
|
| 10 |
UniTmp/HTP
|
https://htp.unitmp.org
|
2023 |
64945
|
69411
|
|
|
The Human Transmembrane Proteome database and web service are a comprehensive resources of the α-helical human transmembrane proteins. It contains topology and structure information about the human α-helical transmembrane proteins classified into reliability levels.
|
| 11 |
UniTmp/TOPDB
|
https://topdb.unitmp.org
|
2023 |
533196
|
265917
|
|
|
The Topology Data Bank of Transmembrane Proteins (TOPDB) is a complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information. The database collects the details of various experiments carried out to learn about the topology of particular transmembrane proteins.
|
| 12 |
UniTmp/TOPDOM
|
https://topdom.unitmp.org
|
2023 |
5835
|
97405
|
|
|
TOPDOM is a collection of domains and sequence motifs located conservatively in one side of transmembrane proteins.
|
| 13 |
BETA
|
https://beta.pbrg.hu
|
2024 |
18691
|
22
|
|
|
BETA provides datasets of structures and sequences that were not used during AlphaFold2 training.
|
|
Sum |
|
|
4796814 |
6330587 |