Servers and databases

# Name Url Year Visitors Completed tasks/downloads
1 CCTOP https://cctop.ttk.hu 2014 2823739 2881244
CCTOP predicts the topology i.e. localization of membrane spanning regions and orientation of segments between them for transmembrane proteins. The prediction is a consensus of 10 different methods enchanced with available structural and experimental information of any homologous proteins in the TOPDB database.
2 TSTMP http://tstmp.enzim.ttk.mta.hu 2016 389878 32222
TSTMP is a database designed to help the target selection of human transmembrane proteins for structural genomics projects.
3 HTP This server was shut down in 2023. 2016 315017 n.a.
The Human Transmembrane Proteome database and web service are a comprehensive resources of the α-helical human transmembrane proteins. It contains topology and structure information about the human α-helical transmembrane proteins classified into reliability levels.
4 PolarProtDb https://polarprotdb.ttk.hu 2020 162475 1553
PolarProtDb is the most comprehensive database containing experimentally verified mammalian proteins that display polarized sorting or secretion, focusing at epithelial polarity. In addition to the source cells or tissues, homology-based inferences and transmembrane topology (if applicable) are all provided together.
5 MemDis https://memdis.ttk.hu 2020 2355 21021
MEMDIS is a novel prediction method, utilizing convolutional neural network and long short-term memory networks for predicting disordered regions in TMPs. MEMDIS achieved the highest prediction accuracy on TMP specific dataset among other popular IDR prediction methods.
6 PolarProtPred https://polarprotpred.ttk.hu 2021 7185 39292
PolarProtPred may offer help to experimentalists to identify or better characterize molecular networks regulating the distribution of transporters or surface receptors (including viral entry receptors like COVID-19) by predicting polar distribution of transmembrane proteins.
7 TmAlphaFold https://tmalphafold.ttk.hu 2022 34845 293899
TmAlphaFold database provides open access to the membrane orientation of all alpha-helical transmembrane protein's structure predicted by AlphaFold together with the evaluation of the predicted structures.
8 LeishMANIAdb https://leishmaniadb.ttk.hu 2023 1285 167871
The leishMANIAdb contains experimental, computational and annotated information about proteins from Leishmania species.
9 UniTmp/PDBTM https://pdbtm.unitmp.org 2023 242387 575248
PDBTM is the first comprehensive and up-to-date transmembrane protein selection of the Protein Data Bank (PDB). The database was created by scanning all PDB entries with TMDET algorithm.
10 UniTmp/HTP https://htp.unitmp.org 2023 43398 26700
The Human Transmembrane Proteome database and web service are a comprehensive resources of the α-helical human transmembrane proteins. It contains topology and structure information about the human α-helical transmembrane proteins classified into reliability levels.
11 UniTmp/TOPDB https://topdb.unitmp.org 2023 140408 246602
The Topology Data Bank of Transmembrane Proteins (TOPDB) is a complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information. The database collects the details of various experiments carried out to learn about the topology of particular transmembrane proteins.
12 UniTmp/TOPDOM https://topdom.unitmp.org 2023 5835 42074
TOPDOM is a collection of domains and sequence motifs located conservatively in one side of transmembrane proteins.
13 BETA https://beta.pbrg.hu 2024 1220 3
BETA provides datasets of structures and sequences that were not used during AlphaFold2 training.
Sum 4170027 4327729