Servers and databases

# Name Url Year Visitors Completed tasks/downloads
1 BiSearch http://bisearch.enzim.hu 2004 1192444 4595684
BiSearch is a primer-design algorithm for DNA sequences. It may be used for both bisulfite converted as well as for original not modified sequences. Users can search various genomes with the designed primers to avoid non-specific PCR products.
2 CMWeb http://cmweb.enzim.hu 2012 1107425 8253
Contact Map WebViewer (or shortly, CMWeb) is an online tool for studying basic properties of residue-residue contact formation and contact clusters.
3 HMMTOP http://www.enzim.hu/hmmtop 1999 1355960 15174914
HMMTOP predicts topology of transmembrane proteins (i.e. number and positions of transmembrane helices in the amino acid sequences, and the orientation of sequence parts between helices relative to the membrane). It utilizes an unsupervised learning algorithm for the prediction and uses amino acid sequence as input.
4 PDBTM This server was shut down in 2023. 2004 975305 72487
PDBTM is the first comprehensive and up-to-date transmembrane protein selection of the Protein Data Bank (PDB). The database was created by scanning all PDB entries with TMDET algorithm.
5 PSORT-B http://www.psort.org/psortb 2003 n.a. n.a.
PSORT-B is an updated method of PSORT family for prediction of localization in Gram-negative bacterial proteins.
6 SCIDE This server was shut down in 2015. 1997 n.a. n.a.
SCIDE can identify the stabilization center residues in known protein structures.
7 SRide http://sride.enzim.hu 2005 18214 n.a.
SRide identifies residues expected to play key roles in the stabilization of proteins.
8 TMDET http://tmdet.enzim.hu 2005 515209 110130
TMDET is an online tool for the detection of the transmembrane regions of membrane proteins by using their 3D structure only.
9 TOPDB This server was shut down in 2023. 2008 720126 204426
The Topology Data Bank of Transmembrane Proteins (TOPDB) is a complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information. The database collects the details of various experiments carried out to learn about the topology of particular transmembrane proteins.
10 TOPDOM This server was shut down in 2023. 2008 607665 1135655
TOPDOM is a collection of domains and sequence motifs located conservatively in one side of transmembrane proteins.
11 TmFoldWeb This server was shut down in 2021. 2015 15843 1725
TMFoldWeb is a web server for recognizing the fold of the membrane segments of transmembrane proteins based on statistical potentials and a topology filtering approach.
12 dt40 http://dt40.enzim.ttk.mta.hu 2015 40019 24025
In the dt40 homepage a de novo assembly of the DT40 genome can be downloaded or BLAST searched. Further files with information about the DT40 genome and web links are also provided.
13 TSTMP http://tstmp.enzim.ttk.mta.hu 2016 389588 32204
TSTMP is a database designed to help the target selection of human transmembrane proteins for structural genomics projects.
14 TMCrys http://tmcrys.enzim.ttk.mta.hu 2018 23180 2855
TMCrys predicts the probability of successful solubilization, purification and crystallization of transmembrane proteins as well as the success for all these three steps together.
15 PolarProtDb http://polarprotdb.ttk.hu 2020 130445 1403
PolarProtDb is the most comprehensive database containing experimentally verified mammalian proteins that display polarized sorting or secretion, focusing at epithelial polarity. In addition to the source cells or tissues, homology-based inferences and transmembrane topology (if applicable) are all provided together.
16 PolarProtPred http://polarprotpred.ttk.hu 2021 6388 39016
PolarProtPred may offer help to experimentalists to identify or better characterize molecular networks regulating the distribution of transporters or surface receptors (including viral entry receptors like COVID-19) by predicting polar distribution of transmembrane proteins.
17 CCTOP http://cctop.ttk.hu 2014 2793884 2843528
CCTOP predicts the topology i.e. localization of membrane spanning regions and orientation of segments between them for transmembrane proteins. The prediction is a consensus of 10 different methods enchanced with available structural and experimental information of any homologous proteins in the TOPDB database.
18 HTP This server was shut down in 2023. 2016 315017 n.a.
The Human Transmembrane Proteome database and web service are a comprehensive resources of the α-helical human transmembrane proteins. It contains topology and structure information about the human α-helical transmembrane proteins classified into reliability levels.
19 TmAlphaFold http://tmalphafold.ttk.hu 2022 32978 266119
TmAlphaFold database provides open access to the membrane orientation of all alpha-helical transmembrane protein's structure predicted by AlphaFold together with the evaluation of the predicted structures.
20 LeishMANIAdb http://leishmaniadb.ttk.hu 2023 698 43231
The leishMANIAdb contains experimental, computational and annotated information about proteins from Leishmania species.
21 MFIB http://mfib.enzim.ttk.mta.hu 2017 n.a. n.a.
Mutual Folding Induced by Binding (MFIB) database is a repository for protein complexes that are formed exclusively by intrinsically unstructured proteins (IUPs). As these proteins have no stable tertiary structure in their monomeric form, their folding is induced by the assembly of the complex.
22 UniTmp/PDBTM https://pdbtm.unitmp.org 2023 216771 470936
PDBTM is the first comprehensive and up-to-date transmembrane protein selection of the Protein Data Bank (PDB). The database was created by scanning all PDB entries with TMDET algorithm.
23 UniTmp/HTP https://htp.unitmp.org 2023 31270 16563
The Human Transmembrane Proteome database and web service are a comprehensive resources of the α-helical human transmembrane proteins. It contains topology and structure information about the human α-helical transmembrane proteins classified into reliability levels.
24 UniTmp/TOPDB https://topdb.unitmp.org 2023 74920 242844
The Topology Data Bank of Transmembrane Proteins (TOPDB) is a complete and comprehensive collection of transmembrane protein datasets containing experimentally derived topology information. The database collects the details of various experiments carried out to learn about the topology of particular transmembrane proteins.
25 UniTmp/TOPDOM https://topdom.unitmp.org 2023 5835 31433
TOPDOM is a collection of domains and sequence motifs located conservatively in one side of transmembrane proteins.
Sum 10569184 25317431